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首页- Products - Others - Other Targets - Balsalazide disodium salt dihydrate

Balsalazide disodium salt dihydrate

CAS No. 150399-21-6

Balsalazide disodium salt dihydrate ( Balsalazide Disodium | balsalazide | BX 661A | Colazal | Colazide )

产品货号. M18055 CAS No. 150399-21-6

Balsalazide 是一种抗炎化合物,用于治疗炎症性肠病。Balsalazide 是一种新的含有 5-氨基水杨酸 (5-ASA) 的前药。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
25MG ¥1061 有现货
100MG ¥2454 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Balsalazide disodium salt dihydrate
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Balsalazide 是一种抗炎化合物,用于治疗炎症性肠病。Balsalazide 是一种新的含有 5-氨基水杨酸 (5-ASA) 的前药。
  • 产品描述
    Balsalazide Disodium is the disodium salt form of balsalazide, an aminosalicylate and oral prodrug that is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Mesalazine acts locally on the mucosa of the colon where it diminishes inflammation by blocking the production of arachidonic acid metabolites and other inflammatory agents. Balsalazide disodium is used to treat chronic inflammatory bowel disease.(In Vivo):At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug.
  • 体外实验
    ——
  • 体内实验
    At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug.
  • 同义词
    Balsalazide Disodium | balsalazide | BX 661A | Colazal | Colazide
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    STAT
  • 研究领域
    Inflammation/Immunology
  • 适应症
    ——

化学信息

  • CAS Number
    150399-21-6
  • 分子量
    437.31
  • 分子式
    C17H17N3Na2O8
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 125 mg/mL (285.84 mM)
  • SMILES
    [Na+].[Na+].O.O.O=C([O-])c1cc(ccc1O)/N=N/c2ccc(cc2)C(=O)NCCC([O-])=O
  • 化学全称
    5-[4-(2-Carboxyethylcarbamoyl)phenylazo]salicylic Acid Disodium Salt Dihydrate

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Kruis W, et al. Gut, 2001. 49(6): p. 783-789.
产品手册
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